Contraindicated (one)pentobarbital will lessen the extent or influence of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's Energetic metabolites.pentobarbital will lower the level or result of itraconazole by impacting hepatic/intestinal enzy… Read More

pentobarbital raises toxicity of buprenorphine, extended-performing injection by pharmacodynamic synergism. Modify Therapy/Monitor Carefully. Coadministration of buprenorphine and benzodiazepines or other CNS depressants raises possibility of adverse reactions which includes overdose, respiratory depression, and Dying. Cessation of benzodiazepines … Read More